Results/News Releases
| Date | Opponent | Location | Outcome/Time |
| 09/09/2000 | North Carolina State | Bloomington, Ind. | L, 41-38 |
| 09/16/2000 | Kentucky | Lexington, Ky. | L, 41-34 |
| 09/23/2000 | Cincinnati | Bloomington, Ind. | W, 42-6 |
| 09/30/2000 | Iowa | Bloomington, Ind. | W, 45-33 |
| 10/07/2000 | Northwestern | Evanston, Ill. | L, 52-33 |
| 10/14/2000 | Michigan | Ann Arbor, Mich. | L, 58-0 |
| 10/21/2000 | Minnesota | Bloomington, Ind. | W, 51-43 |
| 10/28/2000 | Penn State | RCA Dome | L, 27-24 |
| 11/04/2000 | Illinois | Champaign, Ill. | L, 42-35 |
| 11/11/2000 | Wisconsin | Bloomington, Ind. | L, 43-22 |
| 11/18/2000 | Purdue | West Lafayette, Ind. | L, 41-13 |
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